Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model
Identifieur interne : 000C24 ( Main/Exploration ); précédent : 000C23; suivant : 000C25Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model
Auteurs : Vincent J. Munster [États-Unis] ; Daniel Wells [Royaume-Uni] ; Teresa Lambe [Royaume-Uni] ; Daniel Wright [Royaume-Uni] ; Robert J. Fischer [États-Unis] ; Trenton Bushmaker [États-Unis] ; Greg Saturday [États-Unis] ; Neeltje Van Doremalen [États-Unis] ; Sarah C. Gilbert [Royaume-Uni] ; Emmie De Wit [États-Unis] ; George M. Warimwe [Royaume-Uni, Kenya]Source :
- NPJ Vaccines [ 2059-0105 ] ; 2017.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic virus that causes severe respiratory disease in humans with a case fatality rate close to 40%, but for which no vaccines are available. Here, we evaluated the utility of ChAdOx1, a promising replication-deficient simian adenovirus vaccine vector platform with an established safety profile in humans and dromedary camels, for MERS-CoV vaccine development. Using a transgenic lethal BALB/c MERS-CoV mouse model we showed that single dose intranasal or intramuscular immunisation with ChAdOx1 MERS, encoding full-length MERS-CoV Spike glycoprotein, is highly immunogenic and confers protection against lethal viral challenge. Immunogenicity and efficacy were comparable between immunisation routes. Together these data provide support for further evaluation of ChAdOx1 MERS vaccine in humans and dromedary camels, the animal reservoir of infection.
Url:
DOI: 10.1038/s41541-017-0029-1
PubMed: 29263883
PubMed Central: 5643297
Affiliations:
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Gilbert</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>The Jenner Institute, University of Oxford,</institution></institution-wrap>Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2164 9667</institution-id><institution-id institution-id-type="GRID">grid.419681.3</institution-id><institution>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health,</institution><institution>Rocky Mountain Laboratories,</institution></institution-wrap>Hamilton, MT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Montana</region></placeName><wicri:cityArea>Hamilton</wicri:cityArea></affiliation></author><author><name sortKey="Warimwe, George M" sort="Warimwe, George M" uniqKey="Warimwe G" first="George M." last="Warimwe">George M. 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Here, we evaluated the utility of ChAdOx1, a promising replication-deficient simian adenovirus vaccine vector platform with an established safety profile in humans and dromedary camels, for MERS-CoV vaccine development. Using a transgenic lethal BALB/c MERS-CoV mouse model we showed that single dose intranasal or intramuscular immunisation with ChAdOx1 MERS, encoding full-length MERS-CoV Spike glycoprotein, is highly immunogenic and confers protection against lethal viral challenge. Immunogenicity and efficacy were comparable between immunisation routes. Together these data provide support for further evaluation of ChAdOx1 MERS vaccine in humans and dromedary camels, the animal reservoir of infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oboho, Ik" uniqKey="Oboho I">IK Oboho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K Modjarrad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ewer, Kj" uniqKey="Ewer K">KJ Ewer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dicks, Md" uniqKey="Dicks M">MD Dicks</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Alharbi, Kn" uniqKey="Alharbi K">KN Alharbi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agrawal, As" uniqKey="Agrawal A">AS Agrawal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ali, Ma" uniqKey="Ali M">MA Ali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Kenya</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Montana</li></region></list><tree><country name="États-Unis"><region name="Montana"><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name></region><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><name sortKey="Fischer, Robert J" sort="Fischer, Robert J" uniqKey="Fischer R" first="Robert J." last="Fischer">Robert J. Fischer</name><name sortKey="Saturday, Greg" sort="Saturday, Greg" uniqKey="Saturday G" first="Greg" last="Saturday">Greg Saturday</name><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Wells, Daniel" sort="Wells, Daniel" uniqKey="Wells D" first="Daniel" last="Wells">Daniel Wells</name></noRegion><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name><name sortKey="Warimwe, George M" sort="Warimwe, George M" uniqKey="Warimwe G" first="George M." last="Warimwe">George M. Warimwe</name><name sortKey="Warimwe, George M" sort="Warimwe, George M" uniqKey="Warimwe G" first="George M." last="Warimwe">George M. Warimwe</name><name sortKey="Wright, Daniel" sort="Wright, Daniel" uniqKey="Wright D" first="Daniel" last="Wright">Daniel Wright</name></country><country name="Kenya"><noRegion><name sortKey="Warimwe, George M" sort="Warimwe, George M" uniqKey="Warimwe G" first="George M." last="Warimwe">George M. Warimwe</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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